The concept that the immune system can recognize and destroy nascent transformed cells was originally embodied in the cancer immunosurveillance. Request PDF on ResearchGate | Cancer Immunoediting: From Immunosurveillance to Tumor Escape | The concept that the immune system. Cancer Immunoediting from Immunosurveillance to Tumor Escape in Microvillus- Formed Niche: A Study of Syngeneic Orthotopic Rat Bladder.
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Showing of references. Ultrastructural descriptions of heterotypic aggregation between eosinophils and tumor cells in human gastric carcinomas.
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Immunotherapy in head and neck cancer: RNA pulsed dendritic cells: New data, however, clearly show the existence of cancer immunosurveillance and also indicate that it may cancre as a component of a more general process of cancer immunoediting. This paper has been referenced on Twitter tumoor times over the past 90 days. These niches were interconnected with desmosomes between cancer cells and without infiltration of lymphocytes.
Burdach Journal of Translational Medicine RussellTimothy J. Effect of neonatal thymectomy on the induction of sarcomata. Bruce and Hiroaki Ikeda and L.
Cancer immunoediting: from immunosurveillance to tumor escape – Semantic Scholar
WeinerRishi SuranaJoseph C. Modeling putative therapeutic implications of exosome exchange between tumor and immune cells.
Targeted therapeutic remodeling of the tumor microenvironment improves an HER-2 DNA vaccine and prevents recurrence in a murine breast cancer model.
Monitoring, Immunologic Immune system. Lakshmi PrabhaRajeev K. The expression of E-cadherin, selectins, PGP9. Topics Discussed in This Paper.
Ley Annual review of immunology Valiante The Journal of experimental medicine A unique ultrastructure displaying microvillus-formed niches was found in small areas within the tumor of both rats and humans.
We suggest that the microvillus-formed cahcer that harbors a few implanted cancer cells might be the compartment that prevents the tumor eradication by the host immune system.
Fisher rats were inoculated with AY cells a Fisher rat bladder cancer cell line. Abdel-MotalKim M.
Cancer immunoediting: from immunosurveillance to tumor escape.
Aids-related malignancies Chris H. The altered pathways and morphogenesis of this rat model corresponded more closely with those of human muscle-invasive rather than non-muscle-invasive tumors. Citations Publications citing this paper. Results showed that 12 of 24 differentially expressed pathways were concordant in connection to cell cycle and proliferation between rats and humans both non-muscle-invasive and muscle-invasive tumors and that 11 of the 24 pathways, including major histocompatibility complex, were related to host immunosurveillance with activations of Ummunoediting cells and natural killer cells in rats.
References Publications referenced by this paper.
Vaccine prevention of cancer: The aim of the present study was to find evidence for this hypothesis by using a rat orthotopic bladder cancer model. Cultured imjunoediting cells, rat and human bladder cancer tissues, and publicly available microarray data from human bladder cancer were analyzed by means of bioinformatics and morphology.
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Spinning molecular immunology into successful immunotherapy. This paper has highly influenced 39 other papers. StreetJoseph A. Reisfeld Cancer research Murray Cancer prevention research From This Paper Figures, tables, and topics from this paper.